Translational neuroimaging & brain stimulation

BrainMorph In recent years, I have established the Translational Neuroimaging lab within the Vision & Cognition group (Prof. Roelfsema) and in collaboration with the Neuromodulation & Behaviour group of (Prof. Denys, Dr. Willuhn) at the Netherlands Institute for Neuroscience in Amsterdam. Here, we aim to map the functional neural networks that drive cognitive functions and investigate how brain stimulation techniques, like deep brain stimulation can affect these complex neural neural systems and influence behaviour.

Deep brains stimulation of striatal brain areas is a psychiatric treatment option that targets the brain’s reward and motivation circuits. It is used at the Amsterdam UMC and several other centers around the world to treat psychiatric disorders like depression and OCD. In Deep Brain Stimulation, a stimulation electrode is chronically implanted in the patient’s brain. Batteries that are implanted send electrical pulses into the brain that interfere with neural signaling. Whereas, the results of these treatments can be remarkable, the precise local and global effects of stimulation are relatively unknown. This research was launched with support of a VENI-grant from the Netherlands Organization for Scientific Research

Visual perception & awareness

Impossible figureThe vast amount of visual information that surrounds us every day is an important determinant of our behavior and emotions. Due to the surplus of visual information our brain needs to select information and use standard ‘tricks’ to interpret a retinal pattern fast and accurate. Seeing is therefore much more a matter of brains than of eyes. But how does our visual system pick up the relevant aspects of the visual world and what happens in our brain before we become aware of the things we see? One of my longtime research interests deals with these questions using a range of methodological approaches and stimuli.

Bistable stimuli are stimuli that have two, mutually exclusive, perceptual interpretations. Perception however tends to be unitary causing conscious perception to alternate between the individual interpretations over time. The rotating sphere below is an example of a bistable stimulus. Because there is no explicit depth information the sphere can be perceived to rotate either leftwards or rightwards. In binocular rivalry different images are presented to the individual causing a similar perceptual conflict. Temporal and spatial factors influencing the dynamics of conscious visual experience with rivalrous stimuli can provide us with valuable information about how the brain shapes conscious visual perception


Attending to a certain aspect of a visual scene has profound effects of the way that aspect is processed in visual perception. Attention can be directed to such an aspect for (roughly) two reason: 1) The aspect ‘pops out’ of the scene. Think of single blue Chelsea soccer jersey in a crowd of red-shirted Manchester United fans; 2) The observer intentionally pays attention to it, e.g. if he is looking for his lost friend wearing a blue shirt. With the latter type of attention one can (to a certain extent) control how the above-mentioned bistable stimuli are perceived.


Sphere Vision is hardly ever stationary. Imagine yourself cycling through traffic (a typical dutch situation). The traffic is moving around you, you are moving yourself and your eyes as well as your head are moving. Somehow, most of us survive this multi-component motion situation and perception remains remarkably stable. Motion can also be very informative about 3d-shape from 2d-displays (structure-from-motion). Here two things that are classically thought to be represented in different parts of the brain (‘what’ and ‘where’) somehow strongly interact. Understanding motion perception is crucial for understanding visual perception in general.

Two-photon imaging

The brain is a remarkably plastic machine that continuously changes its activity and functional connections in response to novel experiences. In the neurophysiology lab at Utrecht University, we used two-photon excitation microscopy to study neural dynamics at the population and subcellular level. At the population level, we looked at processes of neuronal adaptation and perceptual learning with in vivo recordings of calcium activity in the visual cortex. With Bart Jongbloets and Geert Ramakers from the Rudolph Magnus Institute at the UMC Utrecht we also performed in vitro imaging experiments of dendritic spine dynamics in hippocampal slices.